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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IRAK1
All Species:
15.45
Human Site:
S376
Identified Species:
37.78
UniProt:
P51617
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51617
NP_001020413.1
712
76537
S376
G
S
S
P
S
Q
S
S
M
V
A
R
T
Q
T
Chimpanzee
Pan troglodytes
XP_521332
850
89683
S517
G
S
S
P
S
Q
S
S
M
V
A
R
T
Q
T
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_549367
722
76996
S377
G
A
N
P
G
Q
S
S
T
V
A
R
T
R
T
Cat
Felis silvestris
Mouse
Mus musculus
Q62406
710
77251
S376
G
A
K
A
S
Q
S
S
T
V
A
R
T
S
T
Rat
Rattus norvegicus
Q4QQS0
624
69218
H333
L
H
S
L
D
I
I
H
S
N
V
K
S
A
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508862
872
94244
S484
G
A
S
S
G
R
S
S
S
L
A
R
T
Q
T
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_697688
686
76453
V368
L
K
D
G
Q
L
G
V
E
I
D
A
Y
S
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002312803
404
44281
A113
K
G
W
L
D
E
K
A
P
G
R
I
G
S
G
Maize
Zea mays
NP_001132095
412
44547
Y121
E
G
G
F
G
S
V
Y
R
A
F
F
R
S
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q06548
410
45501
W119
G
W
Q
G
H
Q
E
W
L
A
E
V
N
Y
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
77.1
N.A.
83
N.A.
81
27.6
N.A.
49.4
N.A.
N.A.
36.3
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
78.9
N.A.
87.8
N.A.
85.2
44.9
N.A.
59
N.A.
N.A.
52.5
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
N.A.
66.6
N.A.
66.6
6.6
N.A.
60
N.A.
N.A.
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
N.A.
86.6
N.A.
73.3
20
N.A.
80
N.A.
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
23.8
25.8
N.A.
22.8
N.A.
N.A.
Protein Similarity:
33
36.2
N.A.
35.3
N.A.
N.A.
P-Site Identity:
0
0
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
13.3
0
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
30
0
10
0
0
0
10
0
20
50
10
0
10
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
0
20
0
0
0
0
0
10
0
0
0
0
% D
% Glu:
10
0
0
0
0
10
10
0
10
0
10
0
0
0
0
% E
% Phe:
0
0
0
10
0
0
0
0
0
0
10
10
0
0
10
% F
% Gly:
60
20
10
20
30
0
10
0
0
10
0
0
10
0
10
% G
% His:
0
10
0
0
10
0
0
10
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
10
10
0
0
10
0
10
0
0
0
% I
% Lys:
10
10
10
0
0
0
10
0
0
0
0
10
0
0
0
% K
% Leu:
20
0
0
20
0
10
0
0
10
10
0
0
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
20
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
0
0
0
0
10
0
0
10
0
10
% N
% Pro:
0
0
0
30
0
0
0
0
10
0
0
0
0
0
0
% P
% Gln:
0
0
10
0
10
50
0
0
0
0
0
0
0
30
0
% Q
% Arg:
0
0
0
0
0
10
0
0
10
0
10
50
10
10
0
% R
% Ser:
0
20
40
10
30
10
50
50
20
0
0
0
10
40
0
% S
% Thr:
0
0
0
0
0
0
0
0
20
0
0
0
50
0
50
% T
% Val:
0
0
0
0
0
0
10
10
0
40
10
10
0
0
0
% V
% Trp:
0
10
10
0
0
0
0
10
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
10
0
0
0
0
10
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _